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Probability in Health and Medicine

• Medical uncertainties and probability
• Elementary laws of probability
• Bayes' Rule
• Sensitivity-specificity of a medical test
• Positive and negative predictive value
• Effect of prevalence

Confidence Intervals

• Sampling distributions and SEs
• Large sample CI for one-sample mean and proportion
• Exact CI for proportion and median
• Large sample CI for differences between means and proportions
• The sample size for estimation

Statistical vs. Medical Significance

• P-value and level of significance
• The concept of statistical power
• Medical vs. statistical significance
• The sample size for significance and power analysis
• Chi-square test for simple situations

Some Statistical Tests for Quantitative Data

• Student's t-test for one-sample and two-sample situations
• ANOVA for one-way and two-way tables
• Tukey test and Bonferroni procedures for multiple comparisons
• Test for medically significant gain and equivalence test

Introduction to Designs for Clinical Trials

• Control group
• Randomization and matching
• Blinding and masking
• One-way, two-way, and repeated measures designs
• Cross-over design

ROC Curves

• Review of sensitivity-specificity
• Serial and parallel tests
• ROC curve
• Predictivity-based ROC curve
• Clinical gains from a test

Relative Risk (RR) and Odds Ratio (OR)

• Definitions and applicability of RR and OR
• CI and test of hypothesis for RR
• CI and test of hypothesis for attributable risk
• CI and test of hypothesis for OR

Introductory Survival Analysis

• Censored durations and need for special methods
• Life table method
• Kaplan-Meier method